High Protein Spaghetti Casserole Recipe

If you’re looking for a hearty, nourishing dinner that packs a punch of flavor and muscle-building power, this High Protein Spaghetti Casserole is an absolute winner. Imagine tender spaghetti noodles mingling with savory lean ground beef, rich tomato sauce, and a luscious blend of cheeses all baked to bubbly, golden perfection. This dish balances comfort and nutrition effortlessly, making it a beloved family favorite and a perfect meal to fuel your day with delicious, wholesome ingredients.

Ingredients You’ll Need

Gathering simple yet essential ingredients is the first step to creating this delightful casserole. Each component contributes its own charm—from the robust flavors of lean beef and aromatic spices to the creamy cheeses that add luscious texture and richness.

• 12 oz spaghetti noodles (dry): The classic base that holds all the flavors together with just the right bite when cooked al dente.
• 1 tbsp olive oil: Helps brown the beef evenly while adding a subtle fruity undertone to the dish.
• 1 lb lean ground beef: A protein powerhouse that keeps the casserole hearty yet healthy.
• 2 15 oz cans tomato sauce: Adds a rich, tangy depth and moistness for the perfect sauce consistency.
• 1 15 oz can crushed tomatoes: Introduces texture and a fresh tomato flavor that brightens the sauce.
• 1 tbsp cornstarch: Keeps the sauce thick and velvety without overwhelming it.
• 1 tbsp Italian seasoning: A fragrant mix of herbs that warms the dish with every bite.
• 1 tbsp dried basil: Infuses an aromatic, sweet herb note essential for that classic Italian profile.
• 2 tsp garlic powder: Brings soft, mellow garlic undertones throughout.
• 1 tsp onion powder: Adds a subtle sweetness and complexity to the sauce.
• 1 tbsp Worcestershire sauce: Gives a savory umami lift that intensifies the meaty flavors.
• 1 tsp salt: Balances and enhances every other seasoning and ingredient.
• 1/2 tsp black pepper: For a gentle hint of warmth and spice.
• 1 cup mozzarella cheese (shredded, low fat, divided): Melts beautifully to create a gooey, satisfying cheese topping.
• 1 cup cream cheese (low fat, softened): Adds a silky creaminess that ties all flavors together.
• 1 cup cottage cheese (low-fat): Boosts the protein content and creates a delightful texture contrast.
• Fresh basil (chopped): The perfect fresh finish that adds color and a burst of herbal brightness.

How to Make High Protein Spaghetti Casserole

Step 1: Prepare Your Oven and Dish

Begin by preheating your oven to 350°F. Meanwhile, lightly spray a 13″x9″ casserole dish with oil to ensure your cheesy masterpiece doesn’t stick—this little step also makes cleanup a breeze!

Step 2: Cook the Spaghetti Noodles

Boil the spaghetti noodles following the package instructions until they are perfectly al dente—meaning tender but with a slight bite. Drain and transfer them into a large mixing bowl, ready to be married with the rich beef sauce.

Step 3: Brown the Lean Ground Beef

Heat the olive oil in a large skillet over medium-high heat, then add the lean ground beef. Break it apart gently using a spatula and cook until gloriously browned, which should take about 5 to 7 minutes. This step builds the deep, savory foundation of the casserole’s flavor.

Step 4: Make the Flavorful Sauce

While your beef is cooking, whisk together tomato sauce, crushed tomatoes, cornstarch, Italian seasoning, dried basil, garlic powder, onion powder, Worcestershire sauce, salt, and black pepper in a medium bowl. Once the beef is brown, pour this vibrant sauce mixture into the skillet. Stir to combine, reduce the heat, and let it simmer gently for 15 to 20 minutes. Simmering allows the sauce to thicken beautifully while melding all those wonderful flavors.

Step 5: Combine Spaghetti with Beef Sauce

Add about 2 cups of the beef-sauce mixture into the large bowl with your drained spaghetti. Toss everything well until every noodle is generously coated in that rich, meaty sauce—this ensures each bite tastes as delicious as the last.

Step 6: Prepare the Cheese Mixture

In a small bowl, blend 1/2 cup of shredded mozzarella cheese, softened cream cheese, and cottage cheese until smooth and creamy. This mixture adds a luxurious, protein-packed layer of creaminess that makes the casserole truly irresistible.

Step 7: Assemble the Casserole Layers

Spread half of the remaining beef mixture at the bottom of your prepared casserole dish. Layer half of the spaghetti mixture on top of this, spreading evenly. Next, dollop and spread the creamy cheese mixture over the spaghetti. Then add the remaining half of the spaghetti mixture and finish by topping with the last of the beef sauce. This layered technique creates a beautiful medley of flavors and textures in every forkful.

Step 8: Bake to Perfection

Sprinkle the remaining 1/2 cup mozzarella cheese over the top, cover the dish with foil, and bake in your preheated oven for 30 minutes. Afterward, remove the foil and bake an additional 5 minutes to allow the cheese to turn a gorgeous golden brown and bubble enticingly, creating a cheesy crust that’s simply mouthwatering.

Step 9: Add Fresh Basil and Serve

Once out of the oven, garnish with chopped fresh basil. This final touch adds vibrant color and a fresh herbal aroma that perfectly complements the rich casserole.

How to Serve High Protein Spaghetti Casserole

Garnishes

Fresh chopped basil is a must to brighten the dish visually and add a fragrant herbaceous note. A light drizzle of olive oil or a sprinkle of crushed red pepper flakes can give it an extra dash of flavor and personality depending on your mood.

Side Dishes

This hearty casserole pairs wonderfully with crisp green salads or steamed broccoli to add a crunchy, fresh contrast to the cheesy, tender casserole. Roasted vegetables or garlic bread also make fantastic accompaniments, rounding out the meal with complementary textures and flavors.

Creative Ways to Present

Serve this High Protein Spaghetti Casserole family-style straight from the baking dish for a cozy gathering, or plate individual portions layered carefully to showcase the vibrant layers. For a special touch, add a sprinkle of grated Parmesan and a few basil leaves on each serving plate—it’s like a restaurant-quality presentation in your own home kitchen!

Make Ahead and Storage

Storing Leftovers

Store any leftover casserole in an airtight container in the refrigerator. It will stay fresh and delicious for up to 3 to 4 days, making it perfect for quick lunches or easy dinners later in the week.

Freezing

This casserole freezes beautifully. To freeze, wrap the whole casserole tightly with foil and then plastic wrap to prevent freezer burn. It can be frozen for up to 3 months, ready to thaw and bake whenever you need a comforting meal fast.

Reheating

To reheat, thaw in the fridge overnight if frozen, then bake uncovered at 350°F for about 20-25 minutes or until warmed through and bubbly. Alternatively, single servings reheat well in the microwave for a convenient meal that tastes fresh and satisfying.

FAQs

Can I use ground turkey instead of beef?

Absolutely! Ground turkey is a fantastic lean substitute that works perfectly in this casserole, keeping it light but still full of protein and flavor.

Is there a vegetarian version of this casserole?

You can swap the ground beef with cooked lentils, crumbled tempeh, or a plant-based meat alternative to maintain the protein content while making it vegetarian-friendly.

Can I make this casserole gluten-free?

Yes, simply use gluten-free spaghetti noodles and ensure all your canned sauces are labeled gluten-free—this way, you can enjoy the dish without worry.

What can I use if I don’t have cornstarch?

Flour or arrowroot powder can be good substitutes to thicken the sauce, but just use half the amount and add gradually to achieve the desired thickness.

How can I increase the protein even more?

Add an extra cup of cottage cheese or mix in cooked quinoa with the spaghetti layers for an additional protein boost without altering the flavor significantly.

Final Thoughts

This High Protein Spaghetti Casserole is pure comfort food with a nutritional twist that makes it perfect for any weeknight or meal prep plan. It’s satisfying, flavorful, and packed with wholesome ingredients that energize your body and delight your taste buds. I encourage you to try this recipe—you might just find your new favorite go-to dinner that brings smiles and happy appetites every time.

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