High Protein Spaghetti Casserole Recipe

If you’ve been on the hunt for a comforting dish that truly powers you up without skimping on flavor, the High Protein Spaghetti Casserole is your new best friend. This hearty casserole blends tender spaghetti noodles with lean ground beef and an irresistible tomato sauce, all layered with a rich, creamy cheese mixture that’s pure magic once baked. The perfect balance of textures and deep Italian-inspired flavors makes this casserole an ideal meal for family dinners, meal prepping, or whenever you need something wholesome and satisfying. Plus, the generous protein punch keeps you energized and fueled for whatever’s next on your day’s agenda.

Ingredients You’ll Need

These ingredients might look straightforward, but each one contributes to the wonderful layers of taste, texture, and color that bring our High Protein Spaghetti Casserole to life. From the savory lean ground beef to the creamy cheeses, every component plays an essential role.

• 12 oz spaghetti noodles (dry): The sturdy pasta base that holds everything together with perfect bite.
• 1 tbsp olive oil: Adds a slight richness while helping to brown the beef beautifully.
• 1 lb lean ground beef: The main protein hero, delivering hearty flavor without excess fat.
• 2 15 oz cans tomato sauce: A smooth, tangy foundation for the sauce, full of classic Italian warmth.
• 1 15 oz can crushed tomatoes: Gives great texture and brightness to the sauce.
• 1 tbsp cornstarch: Thickens the sauce for that perfect cling to noodles and beef.
• 1 tbsp Italian seasoning: A fragrant mix that layers herbal notes to the dish.
• 1 tbsp dried basil: Deepens the herbaceous flavor profile with a sweet and slightly peppery touch.
• 2 tsp garlic powder: Intensifies the savory background with bold, comforting garlic essence.
• 1 tsp onion powder: Adds subtle sweetness and complexity without overpowering.
• 1 tbsp Worcestershire sauce: Brings a unique umami punch that rounds out the tomato sauce.
• 1 tsp salt: Enhances every ingredient’s natural flavor beautifully.
• 1/2 tsp black pepper: Offers a gentle heat that wakes up the palate.
• 1 cup mozzarella cheese (shredded, low fat, divided): For gooey, melty goodness sprinkled between layers and on top.
• 1 cup cream cheese (low fat, softened): Adds creaminess that makes each bite luscious and smooth.
• 1 cup cottage cheese (low-fat): A protein-packed addition for richness and a bit of tang.
• Fresh basil (chopped): Brightens and freshens the finished dish as a delightful garnish.

How to Make High Protein Spaghetti Casserole

Step 1: Preheat and Prep

Begin by setting your oven to 350°F and lightly spray a 13″x9″ casserole dish with oil. This step ensures your casserole will bake evenly and come out without sticking, so cleanup is a breeze.

Step 2: Cook the Spaghetti and Brown the Beef

Bring a large pot of salted water to a boil and cook the spaghetti according to the package instructions until al dente – this gives the pasta just the right bite. Drain and toss into a large bowl. While the pasta cooks, heat olive oil in a skillet over medium-high heat. Add the lean ground beef, breaking it apart with a spatula, and cook for 5-7 minutes until beautifully browned and no longer pink. This browned beef forms a savory foundation that your casserole will build on.

Step 3: Make the Sauce

In a medium bowl, whisk together tomato sauce, crushed tomatoes, cornstarch, Italian seasoning, dried basil, garlic powder, onion powder, Worcestershire sauce, salt, and black pepper. Pour this fragrant mixture into the skillet with your browned beef. Lower the heat and let the sauce simmer for 15-20 minutes, stirring occasionally. The goal here is to reduce the sauce slightly so it thickens without burning, intensifying that rich tomato and herb flavor.

Step 4: Combine Sauce with Spaghetti

Add about 2 cups of your savory beef and sauce mixture to the bowl of cooked spaghetti. Toss it well so every strand gets luxuriously coated with those bold flavors.

Step 5: Prepare the Cheese Mixture

In a small bowl, blend 1/2 cup mozzarella cheese with the softened cream cheese and cottage cheese. This creamy trio layers moisture and protein into the casserole, making each bite indulgent yet balanced.

Step 6: Assemble the Casserole

Spread half of the remaining beef mixture evenly across the bottom of your prepared casserole dish — this first layer creates a saucy base. Next, add half of the spaghetti mixture on top. Spread the entire cheese mixture evenly over the spaghetti, adding a luscious creamy layer. Then, pile on the remaining spaghetti mixture followed by the last of the beef and sauce mixture. Finish by sprinkling the remaining 1/2 cup of mozzarella over the top. Cover the dish with foil and place it in the oven to bake for 30 minutes.

Step 7: Bake to Gooey Perfection

After 30 minutes, remove the foil and bake uncovered for another 5 minutes. This final step browns and bubbles the cheese on top, creating a golden, irresistible crust that invites you in.

Step 8: Garnish and Serve

Scatter freshly chopped basil over the hot casserole just before serving to add a splash of bright color and fresh herbal aroma that perfectly complements the baked cheesy layers.

How to Serve High Protein Spaghetti Casserole

Garnishes

Fresh basil isn’t the only way to brighten this dish. Consider a sprinkle of grated Parmesan or a drizzle of extra virgin olive oil for a glossy finish. A pinch of red pepper flakes also adds a little kick if you love things spicy.

Side Dishes

The hearty nature of this casserole means lighter sides work best. A crisp green salad with a lemon vinaigrette or steamed roasted vegetables balance out the rich casserole perfectly, keeping the meal both nutritious and satisfying.

Creative Ways to Present

For gatherings, serve this dish in individual ramekins for a charming personal touch or scoop generous portions into shallow bowls topped with additional fresh herbs and cracked black pepper to impress your guests with effortless style.

Make Ahead and Storage

Storing Leftovers

Wrap tightly and refrigerate leftover High Protein Spaghetti Casserole in an airtight container. It stays fresh for up to 3 days, making it a convenient and delicious option for quick lunches or dinners later in the week.

Freezing

If you want to save it longer, this casserole freezes beautifully. Place portions in sealed freezer-safe containers or wrap the entire casserole dish tightly with foil and plastic wrap before freezing. It will last up to 3 months, ready whenever you need a nutritious, satisfying meal.

Reheating

Reheat leftovers in the microwave or oven. For best results, warm in a 350°F oven covered with foil until heated through to keep the cheese creamy and prevent drying out. A quick sprinkle of fresh basil after reheating will refresh the flavors.

FAQs

Can I use ground turkey instead of ground beef?

Absolutely! Ground turkey is a lean alternative that works wonderfully in this High Protein Spaghetti Casserole, offering a lighter flavor with the same great protein boost.

Is it possible to make this casserole gluten-free?

Yes! Simply swap the spaghetti noodles for gluten-free pasta. The rest of the ingredients are naturally gluten-free, so you won’t miss a thing.

How can I add more vegetables to the casserole?

Great question! Consider stirring in sautéed mushrooms, spinach, zucchini, or bell peppers with the beef sauce to sneak in extra nutrients and texture.

What’s the best way to prevent the casserole from becoming watery?

Be sure to simmer the sauce long enough for excess water to evaporate and use al dente pasta that won’t release extra moisture during baking. The cornstarch also helps thicken the sauce beautifully.

Can I prepare this casserole a day in advance?

Definitely! Assemble the casserole the day before, cover, and store it in the fridge. Bake it fresh the next day for an easy, time-saving dinner that feels homemade.

Final Thoughts

There is something truly special about this High Protein Spaghetti Casserole — it’s like a warm hug on a plate that delivers both comfort and nourishment. Whether you’re feeding a hungry family or meal prepping for busy days, this dish fits the bill perfectly. Don’t hesitate to give it a try soon; I promise it will become one of your favorite go-to recipes for satisfying, wholesome meals!

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